Dorsal view of 24 hour old zebrafish embryo in which developing neural crest cells are fluorescently labeled (white cells)

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Journal articles (since joining WashU)

  1. Kramer ET*, Godoy PM*, and Kaufman CK. Cross-species analysis reveals unique and shared roles of Sox9 and Sox10 (SOXE family) transcription factors in melanoma. bioRxiv 2022, 2022.12.05.519210
  2. Godoy PM, Zarov AP, and Kaufman CK. Functional analysis of recurrent non-coding variants in human melanoma. bioRxiv. 2022, 2022.06.30.498319.  
  3. Kramer ET, Godoy PM, and Kaufman CK. Transcriptional Profile and Chromatin Accessibility in Zebrafish Melanocytes and Melanoma Tumors. G3 (Bethesda). 2021, Nov 15;jkab379. PMID: 34791221
  4. Naser F, Jackstadt M, Fowle-Grider R, Spalding JL, Cho K, Stancliffe E, Kramer E, Yao L, Krasnick B, Ding L, Fields R, Kaufman CK, Johnson S, and Patti GJ. Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver. Cell Metabolism. 2021 Jul 6;33(7):1493-1504.e5. PMID: 33989520.
  5. Jang HS, Chen Y, Wilkening AN, Ge J, Hou Y, Lee HJ, Choi YR, Lowdon RF, Xing X, Li D, Kaufman CK, Johnson SL, and Wang T. Epigenetic dynamics shaping melanocyte and iridophore cell fate in zebrafish. Genome Biology. 2021 October;22, Article number: 282. PMID: 34607603
  6. Newcomer K, Robbins K, Perone J, Hinojosa FL, Chen D, Jones S, Kaufman CK, Weiser R, Fields R, and Tyler DS. Malignant Melanoma: Evolving Practice Management in an Era of Increasingly Effective Systemic Therapies. Curr Prob Surg, Accepted, June 2021.
  7. Cunningham RL, Kramer ET, DeGeorgia SK, Godoy PM, Zarov AP, Seneviratne S, Grigura V, and Kaufman CK. Functional in vivo characterization of zebrafish sox10 enhancers in melanoma and neural crest. Commun Biol, 4, 695 (2021). PMID: 34099848.
  8. Naser F, Jackstadt M, Fowle-Grider R, Spalding JL, Cho K, Stancliffe E, Kramer E, Yao L, Krasnick B, Ding L, Fields R, Kaufman CK, Johnson S, and Patti GJ. Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver. Cell Metabolism, 2021 July 6; 33.
  9. Patton E, Mueller KL, Adams DJ, N Anandasabapathy, Aplin AE, Bertolotto C, Bosenberg M, Ceol CJ, Chi P, Herlyn M, Holmen SL, Karreth FA, Kaufman CK, Khan S, Kobold S, Leucci E, Levy C, Lombard DB, Lund AW, Marie KL, Marine J-C, Marais R, Martin McMahon, Robles- Espinoza CD, Ronai ZA, Samuels Y, Soengas MS, Villanueva J, Weeraratna AT, White RM, Yeh I, Zhu J, Zon LI, Hurlbert MS, and Merlino G. Melanoma Models for the Next Generation of Therapies. Cancer Cell, 2021 Feb 4;S1535-6108(21)00055-6. PMID: 33545064.
  10. Grigura V, Barbier M, Zarov AP, and Kaufman CK. Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model. Biol Open. 2018 Jan 23; 7:bio030726. PMID 29362277.

Journal articles (including work from postdoc)

  1. He S, Zimmerman M, Layden HM, Berezovskaya A, Etchin J, Martel MW, Thurston G, Jing C-B, van Rooijen E, Kaufman CK, Rodig SJ, Zon LI, Patton L, Mansour M, and Look AT. Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene, Accepted, June 2021.
  2. Fazio M, Van Rooijen E, Dang M, van de Hoek G, Ablain J, Mito JK, Yang S, Pessina P, Thomas A, Michael J, Fabo T, Kaufman CK, Zhou Y, White RM, and Zon LI. Epigenetic reprogramming to neural crest fate drives melanoma development. eLife, 2021;10:e64370 PMID:33527896
  3. Makarova N, Kalaparthi V, Wang A, Williams C, Dokukin ME, Kaufman CK, Zon L, and Sokolov I. Difference in biophysical properties of cancer-initiating cells in melanoma mutated zebrafish. Mech Behav Biomed Mater. 2020 July;107:103746. PMID 32364948.
  4. Parker HJ, De Kumar B, Green SA, Prummel KD, Hess C, Kaufman CK, Mosimann C, Wiedemann LM, Bronner ME, and Krumlauf R. A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates. Nat Commun. 2019 Mar 13;10(1):1189. PMID 30867425
  5. Ciarlo C, Kaufman CK, Kinikoglu B, Michael J, D’Amato C, Yang S, Blokzijl-Franke S, den Hertog J, Schlaeger TM, Zhou Y, Liao EC, and Zon LI. A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. 2017 Aug 23; 6:e29145. PMID 29362277
  6. Fazio M, Avagyan S, van Rooijen E, Mannherz W, Kaufman CK, Lobbardi R ,Langenau RM, and Zon LI. Efficient transduction of zebrafish melanoma cell lines and embryos using VSV-G pseudo-typed lentiviral vectors. 2017 Aug;14(4):379-382. PMID:28557653
  7. Perry EB, Makohon-Moore A, Zheng C, Kaufman CK, Cai J, Iacobuzio-Donahue C, and White RM. Tumor diversity and evolution revealed through RADseq. Oncotarget. Epub June 3, 2017. PMID:28611298
  8. Hockman D, Burns A, Schlosser G, Gates KP, Jevans B, Mongera A, Fisher S, Unlu G, Knapik EW, Kaufman CK, Mosimann C, Zon LI, Lancman JJ, Dong PD, Lickert H, Tucker AS, Baker CV. Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. Elife. 2017 Apr 7;6. pii: e21231. PMID 28387645
  9. Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller A-C, Santoriello C, Liao EC, Young RA, and Zon LI. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science. 2016; 351:aad2197. PMID: 26823433
  10. Heilmann S, Ratnakumar K, Langdon E, Kansler E, Kim I, Campbell NR, Perry E, McMahon A, Kaufman CK, van Rooijen E, Lee W, Iacobuzio-Donahue C, Hynes R, Zon L, Xavier J, White RM. A quantitative system for studying metastasis using transparent zebrafish. Cancer Research. 2015; 75:4272-82. PMID: 26282170
  11. Kong Y, Grimaldi M, Curtin E, Dougherty M, Kaufman C, White RM, Zon LI, and Liao EC. Nitric oxide signaling and histone acetylation coordinate cranial neural crest patterning, differentiation and convergence during craniofacial morphogenesis. Chemistry and Biology. 2014; 21:1-14. PMID: 24684905
  12. Yen J, White RM, Wedge DC, Van Loo P, de Ridder J, Capper A, Richardson J, Jones D, Raine K, Watson I, Wu C-J, Cheng J, Martincorena I, Nik-Zainal S, Mudie L, Moreau Y, Marshall J, Ramakrishna M, Tarpey P, Shlien A, Whitmore I, Gamble S, Latimer C, Langdon E, Kaufman C, Dovey M, Taylor A, Menzies A, McLaren S, O’Meara S, Butler A, Teague J, Lister J, Chin L, Campbell P, Adams DJ, Zon LI, Patton EE, Stemple DL, and Futreal PA. The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome Biology. 2013; 14:R113. PMID: 24148783
  13. Tamplin, O. J., White, R. M., Jing, L., Kaufman, CK, Lacadie, S. A., Li, P., et al. Small molecule screening in zebrafish: swimming in potential drug therapies. Wiley Interdisciplinary Reviews: Developmental Biology. 2012; 1:459–468. PMID: 23801494
  14. White RM, Cech J, Burke CJ, Ratanasirintrawoot S, Chen F, Long H, Kramer M, Tomlinson M, Mosher J, Morrison S, Kaufman C, Datta S, Granter S, Wheeler G, and Zon LI. Inhibitors of DHODH suppress neural crest development and melanoma growth. Nature. 2011; 471:518-522. PMID: 21430780
  15. Mosimann C, Kaufman CK, Li P, Pugach E, Tamplin OJ, and Zon LI. Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin (ubi) promoter in zebrafish. Development. 2011; 138:169-177. PMID: 21138979
  16. Kaufman CK*, White RM*, and Zon, L. Chemical Genetic Screening in the Zebrafish Embryo. Nature Protocols. 2009; 4:1422-1432. PMID: 19745824
  17. Kaufman CK, Zhou P, Pasolli HA, Rendl M, Bolotin D, Lim K-C, Dai X, Alegre ML, and Fuchs E. GATA-3: An unexpected regulator of cell lineage determination in skin. Genes Dev. 2003; 17:2108-2122. PMID: 12923059
  18. Kaufman CK*, Sinha S*, Bolotin D, Fan J, and Fuchs E. Dissection of a complex enhancer element: Maintenance of keratinocyte specificity but loss of differentiation specificity. Mol Cell Biol. 2002; 22:4293-4308. PMID: 12024040
  19. Kaufman CK and Fuchs E. It’s got you covered. NF-kB in the epidermis. J Cell Biol. 2000; 149:999-1004. PMID: 10831603
  20. Cullen PJ*, Kaufman CK*, Bowman WC, and Kranz RG. Characterization of the Rhodobacter capsulatus housekeeping RNA polymerase. In vitro transcription of photosynthesis and other genes. J Biol Chem. 1997; 272:27266-27273. PMID: 9341173

* Authors contributed equally

Book chapters

  1. Kaufman, CK. “Zebrafish Melanoma.” In David Langenau (ed.), Cancer and Zebrafish: Mechanisms, Techniques, and Models. Springer. 2016; 916:439-50. PMID 27165365